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NUP98 antibody [2H10]
GTX00697
- Brand
- GeneTex
- Application
- Dot
ELISA
ICC/IF
WB
- Storage Conditions
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
- Note
- For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption
- Synonyms
- nucleoporin 98 , ADIR2 , NUP196 , NUP96
- Background
- Nuclear pore complexes (NPCs) regulate the transport of macromolecules between the nucleus and cytoplasm, and are composed of many polypeptide subunits, many of which belong to the nucleoporin family. This gene belongs to the nucleoporin gene family and encodes a 186 kDa precursor protein that undergoes autoproteolytic cleavage to generate a 98 kDa nucleoporin and 96 kDa nucleoporin. The 98 kDa nucleoporin contains a Gly-Leu-Phe-Gly (GLGF) repeat domain and participates in many cellular processes, including nuclear import, nuclear export, mitotic progression, and regulation of gene expression. The 96 kDa nucleoporin is a scaffold component of the NPC. Proteolytic cleavage is important for targeting of the proteins to the NPC. Translocations between this gene and many other partner genes have been observed in different leukemias. Rearrangements typically result in chimeras with the N-terminal GLGF domain of this gene to the C-terminus of the partner gene. Alternative splicing results in multiple transcript variants encoding different isoforms, at least two of which are proteolytically processed. Some variants lack the region that encodes the 96 kDa nucleoporin. [provided by RefSeq, Feb 2016]
- Specificity
- We do not recommend use of this product for Tetrahymena.
- Clone Name
- 2H10
- Host
- Rat
- Clonality
- Monoclonal
- Conjugation
- Unconjugated
- Isotype
- IgG2c
- Antigen Species
- Human
- Purification
- Purified IgG
- Concentration
- 1 mg/ml (Please refer to the vial label for the specific concentration.)
- Shipping Temperature
- 4
- Immunogen
- Recombinant GST-fused human Nup98 (amino acids 1-466)
- Buffer
- Filter-sterilized PBS, 50% Glycerol
- Gene ID
- 4928
- Fullname
- nucleoporin 98
- Uniport ID
- P52948
- Calculated MW
- 198
- Application Note
- WB: Assay dependent. ICC/IF: Assay dependent. Dot: Assay dependent. ELISA: Assay dependent. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- Reactivity
- Human
Mouse
Rat
Saccharomyces cerevisiae
Schizosaccharomyces pombe
- Form
- Liquid
- 5 Pillars Validation
- Comparison
- Product Type
- Primary Antibodies
- Product Link
- https://www.genetex.com/Product/Detail/NUP98-antibody-2H10/GTX00697