![Dystrophin antibody [Dy4/6D3]](https://www.axilscientific.com/16913-superlarge_default/dystrophin-antibody-dy4-6d3-.jpg)
Dystrophin antibody [Dy4/6D3]
GTX01871
- Brand
- GeneTex
- Application
- IHC-Fr
- Storage Conditions
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
- Note
- For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption
- Synonyms
- dystrophin , BMD , CMD3B , DXS142 , DXS164 , DXS206 , DXS230 , DXS239 , DXS268 , DXS269 , DXS270 , DXS272 , MRX85
- Background
- This gene spans a genomic range of greater than 2 Mb and encodes a large protein containing an N-terminal actin-binding domain and multiple spectrin repeats. The encoded protein forms a component of the dystrophin-glycoprotein complex (DGC), which bridges the inner cytoskeleton and the extracellular matrix. Deletions, duplications, and point mutations at this gene locus may cause Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD), or cardiomyopathy. Alternative promoter usage and alternative splicing result in numerous distinct transcript variants and protein isoforms for this gene. [provided by RefSeq, Dec 2016]
- Specificity
- This antibody reacts strongly with the rod domain (between amino acids 1181 and 1388) of human dystrophin. No reactivity with mdx mouse tissue of DMD/BMD patients who have a gene deletion which removes the antibody binding site.,We do not recommend use of
- Clone Name
- Dy4/6D3
- Host
- Mouse
- Clonality
- Monoclonal
- Conjugation
- Unconjugated
- Isotype
- IgG2a
- Antigen Species
- Human
- Purification
- Unpurified
- Shipping Temperature
- 4
- Immunogen
- Bacterial fusion protein (Hoffman EP et al., 1987).
- Buffer
- Tissue culture supernatant
- Gene ID
- 1756
- Fullname
- dystrophin
- Uniport ID
- P11532
- Calculated MW
- 427
- Application Note
- IHC-Fr: 1:20. Freeze specimen tissue blocks in isopentane chilled in liquid nitrogen.. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- Reactivity
- Dog
Hamster
Human
Mouse
Pig
Rabbit
Rat
- Form
- Liquid
- Product Type
- Primary Antibodies
- Product Link
- https://www.genetex.com/Product/Detail/Dystrophin-antibody-Dy4-6D3/GTX01871