Rabbit anti-APC Antibody, Affinity Purified
Brand:
A300-979A-T
- Brand
- Bethyl Laboratories
- Application
- IHC
IP
- Storage Conditions
- 2 - 8° C
- Host
- Rabbit
- Conjugation
- Unconjugated
- Immunogen
- between 1 and 50
- Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
- Reactivity
- Human
- Target
- APC
- Shelf Life
- 1 year from date of receipt
- Antibody Type
- Polyclonal
- Alternate Names
- adenomatosis polyposis coli tumor suppressor, adenomatous polyposis coli (APC), adenomatous polyposis coli protein, BTPS2, deleted in polyposis 2.5, DP2, DP2.5, DP3, epididymis secretory sperm binding protein, GS, PPP1R46, Protein APC, protein phosphatase 1, regulatory subunit 46, truncated adenomatosis polyposis coli, WNT signaling pathway regulator
- Format
- Whole IgG
- Presumed Reactivity
- Based on 100% sequence identity, this antibody is predicted to react with Mouse and Rat
- Product Type
- Primary Antibodies
- Product Sub Types
- Primary Antibodies
- UNSPSC
- 12352203
- Western Blot (WB)
- Not recommended
- Immunoprecipitation (IP)
- 2 - 5 µg/mg lysate
- Immunohistochemistry (IHC)
- 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
- Target Sentence
- Adenomatosis polyposis coli (APC) is a tumor suppressor gene found to be mutated in most colon cancers and is the cause of familial adenomatous polyposis (FAP), an autosomal dominant disease that results in a predisposition to malignant colon cancer. APC has been shown to be involved in cell differentiation, migration, proliferation and adhesion. One function of APC involves its role as a scaffolding protein that regulates the phosphorylation and degradation of beta-catenin, a transcriptional regulator in the WNT signaling pathway. Additionally, APC has been found to be important in the regulation of microtubule arrays and mitotic spindle formation.
- Product Link
- http://www.bethyl.com/product/A300-979A
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