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Mouse anti-p53 Monoclonal Antibody, Purified [DO-1]
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Brand:
A500-015A-T
- Brand
- Bethyl Laboratories
- Application
- IHC
IP
WB
- Storage Conditions
- 2 - 8° C
- Host
- Mouse
- Conjugation
- Unconjugated
- Immunogen
- Recombinant full length protein corresponding to Human p53 (N terminal). epitope is within aa 20-25
- Buffer
- Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
- Reactivity
- Human
- Target
- p53
- Shelf Life
- 1 year from date of receipt
- Antibody Type
- Monoclonal
- Alternate Names
- antigen NY-CO-13, BCC7, cellular tumor antigen p53, LFS1, mutant tumor protein 53, P53, p53 tumor suppressor, phosphoprotein p53, transformation-related protein 53, TRP53, tumor protein 53, Tumor suppressor p53, tumor supressor p53
- Format
- Whole IgG
- Product Type
- Primary Antibodies
- Product Sub Types
- Primary Antibodies
- UNSPSC
- 12352203
- Western Blot (WB)
- 1:1000
- Immunoprecipitation (IP)
- 20 µl/mg lysate
- Immunohistochemistry (IHC)
- 1:50 - 1:200. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
- Target Sentence
- p53 is a tumor suppressor protein that is mutated or inactivated in over 50% of human cancers. Loss of function defects in p53 are the cause of the autosomal dominant familial cancer syndrome, Li-Fraumeni syndrome (LFS) that is characterized by the development of a diverse set of malignancies at very early ages. At the cellular level p53 is involved in the negative regulation of cell the cycle via its transactivational control of genes required for cell cycle progression. Depending on the physiological circumstance, p53 can promote growth arrest or apoptosis.
- Product Link
- http://www.bethyl.com/product/A500-015A