![Mouse anti-Rictor Monoclonal Antibody [1G3P2C9]](https://www.axilscientific.com/6819-superlarge_default/mouse-anti-rictor-monoclonal-antibody-1g3p2c9-.jpg)
Mouse anti-Rictor Monoclonal Antibody [1G3P2C9]
Brand:
A500-002A-T
- Brand
- Bethyl Laboratories
- Application
- ICC-IF
IHC
IP
WB
- Storage Conditions
- 2 - 8° C
- Host
- Mouse
- Conjugation
- Unconjugated
- Immunogen
- between 1650 and C-term
- Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
- Reactivity
- Human
- Target
- Rictor
- Shelf Life
- 1 year from date of receipt
- Antibody Type
- Monoclonal
- Alternate Names
- AVO3, AVO3 homolog, hAVO3, PIA, pianissimo, rapamycin-insensitive companion of mTOR, TORC2-specific protein AVO3
- Format
- Whole IgG
- Presumed Reactivity
- Based on 100% sequence identity, this antibody is predicted to react with Mouse, Dog, Orangutan, Monkey, Gorilla, Chimpanzee, Northern white-cheeked gibbon and White-tufted-ear marmoset
- Product Type
- Primary Antibodies
- Product Sub Types
- Primary Antibodies
- UNSPSC
- 12352203
- Western Blot (WB)
- 1:1000
- Immunoprecipitation (IP)
- 3 µl/mg lysate
- Immunohistochemistry (IHC)
- 1:100 - 1:500. Epitope retrieval with Tris-EDTA pH 9.0 is recommended for FFPE tissue sections.
- Immunocytochemistry-Immunofluoresence (ICC-IF)
- 1:500 - 1:2,000
- Target Sentence
- Rictor is a subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q6R327].
- Product Link
- http://www.bethyl.com/product/A500-002A