Rabbit anti-14-3-3 Sigma IHC Antibody, Affinity Purified
Brand:
IHC-00346-T
- Brand
- Bethyl Laboratories
- Application
- IHC
IHC-IF
- Storage Conditions
- 2 - 8° C
- Host
- Rabbit
- Conjugation
- Unconjugated
- Immunogen
- between 198 and 248
- Buffer
- Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
- Reactivity
- Human
- Target
- 14-3-3 Sigma
- Shelf Life
- 1 year from date of receipt
- Antibody Type
- Polyclonal
- Alternate Names
- 14-3-3 protein sigma, epithelial cell marker protein 1, Stratifin, YWHAS
- Format
- Whole IgG
- Product Type
- Primary Antibodies
- Product Sub Types
- Primary Antibodies
- UNSPSC
- 12352203
- Immunohistochemistry (IHC)
- 1:100 - 1:500
- Immunohistochemistry-Immunofluoresence (IHC-IF)
- 1:50 - 1:500
- Target Sentence
- 14-3-3 sigma was identified as an epithelial cell marker. It is part of the 14-3-3 family of proteins in which seven isoforms have been identified: beta, zeta, gamma, eta, epsilon, tau, and sigma. 14-3-3 proteins function as adaptors that bind with a number of partners to mediate various signaling pathways. 14-3-3 sigma is also called stratifin or HME1 and appears to function as a tumor suppressor whose expression can be downregulated via methylation. Loss of 14-3-3 sigma expression results in a defective G2/M phase checkpoint and appears to contribute to both epithelial and non-epithelial tumorigenesis.
- Product Link
- http://www.bethyl.com/product/IHC-00346-T
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