Rabbit anti-AKAP8L/HA95 IHC Antibody, Affinity Purified
Brand:
IHC-00277-T
- Brand
- Bethyl Laboratories
- Application
- IHC
IHC-IF
- Storage Conditions
- 2 - 8° C
- Host
- Rabbit
- Conjugation
- Unconjugated
- Immunogen
- Between 596 and 646
- Buffer
- Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
- Reactivity
- Human
- Target
- AKAP8L/HA95
- Shelf Life
- 1 year from date of receipt
- Antibody Type
- Polyclonal
- Alternate Names
- A kinase (PRKA) anchor protein 8-like, AKAP8-like protein, A-kinase anchor protein 8-like, HA95, HAP95, Helicase A-binding protein 95, helicase A-binding protein 95 kDa, homologous to AKAP95 protein, NAKAP, NAKAP95, neighbor of AKAP95, neighbor of A-kinase anchoring protein 95, Neighbor of A-kinase-anchoring protein 95, testis tissue sperm-binding protein Li 90mP
- Format
- Whole IgG
- Product Type
- Primary Antibodies
- Product Sub Types
- Primary Antibodies
- UNSPSC
- 12352203
- Immunohistochemistry (IHC)
- 1:100 - 1:500
- Immunohistochemistry-Immunofluoresence (IHC-IF)
- 1:50 - 1:500
- Target Sentence
- AKAP8L/HA95 is a PKA anchoring protein that is localized to the nuclear envelope and associates with chromatin upon nuclear envelope breakdown during mitosis. AKAP8L/HA95 has been found to play an important role in the initiation of DNA replication and may function as a scaffold for proteins such as MCM2 and LAP2beta. Additionally, AKAP8L/HA95 has been shown to co-locate with the PKA C subunit in splicing factor compartments and is involved in the regulation of pre-mRNA splicing. Further support for a scaffolding and splicing role in the nucleus comes from the observation that AKAP8L/HA95 colocalizes with HypA, a splicing-like factor, and through this association may function as a docking site for the nuclear accumulation of Huntington protein as seen in Huntington’s disease.
- Product Link
- http://www.bethyl.com/product/IHC-00277-T
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