Rabbit anti-Aly Antibody, Affinity Purified
Brand:
A302-892A-M
- Brand
- Bethyl Laboratories
- Application
- IHC
IP
WB
- Storage Conditions
- 2 - 8° C
- Host
- Rabbit
- Conjugation
- Unconjugated
- Immunogen
- between 25 and 75
- Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
- Reactivity
- Human
- Target
- Aly
- Shelf Life
- 1 year from date of receipt
- Antibody Type
- Polyclonal
- Alternate Names
- ally of AML-1 and LEF-1, ALY, ALY/REF, Aly/REF export factor, BEF, bZIP enhancing factor, bZIP-enhancing factor BEF, REF, THO complex 4, THO complex subunit 4, tho4, THOC4, transcriptional coactivator Aly/REF
- Format
- Whole IgG
- Presumed Reactivity
- Based on 100% sequence identity, this antibody is predicted to react with Bovine
- Product Type
- Primary Antibodies
- Product Sub Types
- Primary Antibodies
- UNSPSC
- 12352203
- Western Blot (WB)
- 1:2,000 - 1:10,000
- Immunoprecipitation (IP)
- 2 - 5 µg/mg lysate
- Immunohistochemistry (IHC)
- 1:1,000 - 1:5,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
- Target Sentence
- Aly (ally of AML-1 and LEF-1) is a component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. Aly also functions as a chaperone and promotes the dimerization of transcription factors containing basic leucine zipper (bZIP) domains and thereby promotes transcriptional activation. Additionally, Aly plays a role in mRNA processing and export and may function as scaffold that mediates interactions between proteins and/or RNA. Aly is also part of the exon junction complex that remains associated with spliced mRNA and plays an important role in mRNA export and nonsense-mediated RNA decay. Aly directs mRNA derived from Herpes simplex virus intron-less genes to the NXF1-mediated export pathway [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q886V81].
- Product Link
- http://www.bethyl.com/product/A302-892A
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