Rabbit anti-BRAP Antibody, Affinity Purified
Brand:
A302-682A-M
- Brand
- Bethyl Laboratories
- Application
- IP
WB
- Storage Conditions
- 2 - 8° C
- Host
- Rabbit
- Conjugation
- Unconjugated
- Immunogen
- between 560 and 592
- Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
- Reactivity
- Human
- Target
- BRAP
- Shelf Life
- 1 year from date of receipt
- Antibody Type
- Polyclonal
- Alternate Names
- BRAP2, BRCA1-associated protein, galectin-2-binding protein, IMP, impedes mitogenic signal propagation, renal carcinoma antigen NY-REN-63, RING finger protein 52, RING-type E3 ubiquitin transferase BRAP2, RNF52
- Format
- Whole IgG
- Product Type
- Primary Antibodies
- Product Sub Types
- Primary Antibodies
- UNSPSC
- 12352203
- Western Blot (WB)
- 1:2,000 - 1:10,000
- Immunoprecipitation (IP)
- 2 - 5 µg/mg lysate
- Target Sentence
- BRCA1-associated protein (BRAP) negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. BRAP acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. BRAP may also act as a cytoplasmic retention protein with a role in regulating nuclear transport [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q7Z569].
- Product Link
- http://www.bethyl.com/product/A302-682A
Related products
