Rabbit anti-CDK6 Antibody, Affinity Purified
Brand:
A304-937A-M
- Brand
- Bethyl Laboratories
- Application
- IP
WB
- Storage Conditions
- 2 - 8° C
- Host
- Rabbit
- Conjugation
- Unconjugated
- Immunogen
- between 250 and 300
- Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
- Reactivity
- Human
- Target
- CDK6
- Shelf Life
- 1 year from date of receipt
- Antibody Type
- Polyclonal
- Alternate Names
- cell division protein kinase 6, cyclin-dependent kinase 6, MCPH12, PLSTIRE, serine/threonine-protein kinase PLSTIRE
- Format
- Whole IgG
- Presumed Reactivity
- Based on 100% sequence identity, this antibody is predicted to react with Mouse
- Product Type
- Primary Antibodies
- Product Sub Types
- Primary Antibodies
- UNSPSC
- 12352203
- Western Blot (WB)
- 1:2,000 - 1:10,000
- Immunoprecipitation (IP)
- Not recommended
- Target Sentence
- Cell division protein kinase 6 is a Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation. CDK6 interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. It is involved in initiation and maintenance of cell cycle exit during cell differentiation. Although, it prevents cell proliferation and regulates negatively cell differentiation, it is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). it is also essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. It may play a role in the centrosome organization during the cell cycle phases (PubMed:23918663) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q00534].
- Product Link
- http://www.bethyl.com/product/A304-937A
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