Rabbit anti-CSN5 Antibody, Affinity Purified
Brand:
A300-014A-M
- Brand
- Bethyl Laboratories
- Application
- IHC
WB
- Storage Conditions
- 2 - 8° C
- Host
- Rabbit
- Conjugation
- Unconjugated
- Immunogen
- between 175 and 225
- Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
- Reactivity
- Human, Mouse
- Target
- CSN5
- Shelf Life
- 1 year from date of receipt
- Antibody Type
- Polyclonal
- Alternate Names
- 38 kDa Mov34 homolog, COP9 constitutive photomorphogenic homolog subunit 5, COP9 signalosome complex subunit 5, CSN5, JAB1, jun activation domain-binding protein 1, MOV-34, SGN5, signalosome subunit 5, testis secretory sperm-binding protein Li 231m
- Format
- Whole IgG
- Presumed Reactivity
- Based on 100% sequence identity, this antibody is predicted to react with Zebrafish, X. laevis and X. tropicalis
- Product Type
- Primary Antibodies
- Product Sub Types
- Primary Antibodies
- UNSPSC
- 12352203
- Western Blot (WB)
- 1:5,000 - 1:25,000
- Immunohistochemistry (IHC)
- 1:250 - 1:2,000. Epitope retrieval with Tris-EDTA pH 9.0 is recommended for FFPE tissue sections.
- Target Sentence
- CSN5 is one of eight subunits (CSN1 to 8) of the highly conserved COP9 signalsome (CSN) complex originally identified as a regulator of light-mediated development in Arabidopsis. Characterization of CSN from yeast to mammals reveals its function as a modulator of signal transduction pathways involved in a variety of cellular and developmental processes. One of the major functions of the CSN is the regulation of protein degradation via intersection with the ubiquitin-proteasome pathway and regulation of E3-ubiquitin ligases. CSN also possesses kinase activity. CSN5 has been identified as the subunit that functions to remove Nedd8, an ubiquitin-like modifier, from cullin-based E3-ubiquitin ligases. CSN5 also functions as a coactivator of nuclear receptors. COP9 signalsome complex subunit 5, signalsome subunit 5, SGN5, jun activation domain-protein 1, COPS5, JAB1, MOV-34, MGC3149.
- Product Link
- http://www.bethyl.com/product/A300-014A
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