Rabbit anti-DIS3L2 Antibody, Affinity Purified
Brand:
A305-859A-M
- Brand
- Bethyl Laboratories
- Application
- WB
- Storage Conditions
- 2 - 8° C
- Host
- Rabbit
- Conjugation
- Unconjugated
- Immunogen
- between 475 and 525
- Buffer
- Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
- Reactivity
- Human
- Target
- DIS3L2
- Shelf Life
- 1 year from date of receipt
- Antibody Type
- Polyclonal
- Alternate Names
- DIS3 mitotic control homolog-like 2, DIS3-like exonuclease 2, FAM6A, family with sequence similarity 6, member A, hDIS3L2, PRLMNS
- Format
- Whole IgG
- Product Type
- Primary Antibodies
- Product Sub Types
- Primary Antibodies
- UNSPSC
- 12352203
- Western Blot (WB)
- 1:1000
- Target Sentence
- DIS3L2 is a 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q8IYB7].
- Product Link
- http://www.bethyl.com/product/A305-859A-T