Rabbit anti-Dorfin Antibody, Affinity Purified
Brand:
A303-105A-T
- Brand
- Bethyl Laboratories
- Application
- IP
- Storage Conditions
- 2 - 8° C
- Host
- Rabbit
- Conjugation
- Unconjugated
- Immunogen
- Between 600 and 650
- Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
- Reactivity
- Human
- Target
- Dorfin
- Shelf Life
- 1 year from date of receipt
- Antibody Type
- Polyclonal
- Alternate Names
- Dorfin, double ring-finger protein, E3 ubiquitin-protein ligase RNF19A, p38, protein p38 interacting with transcription factor Sp1, ring finger protein 19, RING finger protein 19A, ring finger protein 19A, E3 ubiquitin protein ligase, ring-IBR-ring domain containing protein Dorfin, RNF19
- Format
- Whole IgG
- Presumed Reactivity
- Based on 100% sequence identity, this antibody is predicted to react with Pig
- Product Type
- Primary Antibodies
- Product Sub Types
- Primary Antibodies
- UNSPSC
- 12352203
- Western Blot (WB)
- Not recommended. A303-105A has not performed satisfactorily when used for WB of Dorfin in crude preparations (e.g. whole cell lysate). This antibody can be used for WB of enriched (e.g. immunoprecipitated) sources of Dorfin.
- Immunoprecipitation (IP)
- 2 - 10 µg/mg lysate
- Target Sentence
- Dorfin is an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Dorfin specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection.uniprot.org/uniprot/Q9NV58].
- Product Link
- http://www.bethyl.com/product/A303-105A
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