Rabbit anti-ErbB3 Antibody, Affinity Purified
Brand:
A304-370A-M
- Brand
- Bethyl Laboratories
- Application
- IP
WB
- Storage Conditions
- 2 - 8° C
- Host
- Rabbit
- Conjugation
- Unconjugated
- Immunogen
- Between 1292 and 1342
- Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
- Reactivity
- Human
- Target
- ErbB3
- Shelf Life
- 1 year from date of receipt
- Antibody Type
- Polyclonal
- Alternate Names
- c-erbB3, c-erbB-3, ErbB-3, erbB3-S, HER3, human epidermal growth factor receptor 3, LCCS2, MDA-BF-1, p180-ErbB3, p45-sErbB3, p85-sErbB3, proto-oncogene-like protein c-ErbB-3, receptor tyrosine-protein kinase erbB-3, tyrosine kinase-type cell surface receptor HER3, v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
- Format
- Whole IgG
- Presumed Reactivity
- Based on 100% sequence identity, this antibody is predicted to react with Rat and Orangutan
- Product Type
- Primary Antibodies
- Product Sub Types
- Primary Antibodies
- UNSPSC
- 12352203
- Western Blot (WB)
- 1:1,000 - 1:5,000
- Immunoprecipitation (IP)
- 2 - 10 µg/mg lysate
- Target Sentence
- ErbB3, also known as HER3, is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors[taken from NCBI Entrez Gene (Gene ID: 2065)].
- Product Link
- http://www.bethyl.com/product/A304-370A
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