Rabbit anti-FBP17 Antibody, Affinity Purified
Brand:
A302-791A-M
- Brand
- Bethyl Laboratories
- Application
- IP
WB
- Storage Conditions
- 2 - 8° C
- Host
- Rabbit
- Conjugation
- Unconjugated
- Immunogen
- Between 567 and 617
- Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
- Reactivity
- Human
- Target
- FBP17
- Shelf Life
- 1 year from date of receipt
- Antibody Type
- Polyclonal
- Alternate Names
- FBP17, formin-binding protein 1, formin-binding protein 17, hFBP17
- Format
- Whole IgG
- Product Type
- Primary Antibodies
- Product Sub Types
- Primary Antibodies
- UNSPSC
- 12352203
- Western Blot (WB)
- 1:2,000 - 1:10,000
- Immunoprecipitation (IP)
- 5 - 15 µg/mg lysate
- Target Sentence
- FBP17 may act as a link between RND2 signaling and regulation of the actin cytoskeleton. FBP17 is required for the coordination of membrane tubulation and reorganization of the actin cytoskeleton during endocytosis. FBP17 binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. It also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. FBP17 may be required for the lysosomal retention of FASLG/FASL [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q96RU3].
- Product Link
- http://www.bethyl.com/product/A302-791A
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