Rabbit anti-GRLF1/p190RhoGAP Antibody, Affinity Purified
Brand:
A301-736A-M
- Brand
- Bethyl Laboratories
- Application
- IP
WB
- Storage Conditions
- 2 - 8° C
- Host
- Rabbit
- Conjugation
- Unconjugated
- Immunogen
- Between 1200 and 1250
- Buffer
- Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
- Reactivity
- Human, Mouse
- Target
- GRLF1/p190RhoGAP
- Shelf Life
- 1 year from date of receipt
- Antibody Type
- Polyclonal
- Alternate Names
- glucocorticoid receptor DNA-binding factor 1, glucocorticoid receptor repression factor 1, GRF-1, GRLF1, P190A, P190-A, p190ARhoGAP, p190RhoGAP, rho GAP p190A, rho GTPase-activating protein 35
- Format
- Whole IgG
- Presumed Reactivity
- Based on 100% sequence identity, this antibody is predicted to react with Rat and Dog
- Product Type
- Primary Antibodies
- Product Sub Types
- Primary Antibodies
- UNSPSC
- 12352203
- Western Blot (WB)
- 1:2,000 - 1:10,000
- Immunoprecipitation (IP)
- 2 - 5 µg/mg lysate
- Target Sentence
- GRLF1 (glucocorticoid receptor DNA binding factor 1) was first identified as a factor that binds to the regulatory region of the human glucocorticoid receptor (GR) gene and represses GR transcription. Later, p190RhoGAP was identified as a protein that associates with p120RasGAP and through sequence comparison, p190RhoGAP and GRLF1 were determined to be one and the same. GRLF1/P190RhoGAP functions as a GTPase activating protein (GAP) for the Rho GTPase and plays an essential role in mediating cytoskeletal reorganization in response to growth factor signals. p190RhoGAP possesses an unusual GTP binding domain that may serve to regulate its GAP activity and the subsequent modulation of RhoGTPase activity. P190RhoGAP forms a significant complex with p120RasGAP. This association has been suggested to represent a method for the coordination of the Ras and Rho signaling pathways.
- Product Link
- http://www.bethyl.com/product/A301-736A
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