Rabbit anti-Insulin Receptor Beta Antibody, Affinity Purified
Brand:
A303-712A-M
- Brand
- Bethyl Laboratories
- Application
- IP
WB
- Storage Conditions
- 2 - 8° C
- Host
- Rabbit
- Conjugation
- Unconjugated
- Immunogen
- Between 1332 and 1382
- Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
- Reactivity
- Human, Mouse
- Target
- Insulin Receptor Beta
- Shelf Life
- 1 year from date of receipt
- Antibody Type
- Polyclonal
- Alternate Names
- CD antigen CD220, CD220, HHF5, insulin receptor, IR
- Format
- Whole IgG
- Product Type
- Primary Antibodies
- Product Sub Types
- Primary Antibodies
- UNSPSC
- 12352203
- Western Blot (WB)
- 1:2,000 - 1:10,000
- Immunoprecipitation (IP)
- 2 - 10 µg/mg lysate
- Target Sentence
- The insulin receptor is a receptor tyrosine kinase that mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates to stimulate uptake of glucose. The insulin receptor is synthesized as a single polypeptide that is cleaved to generate an alpha and beta subunit. The subunit structure of the insulin receptor consists of a tetramer of two alpha and two beta chains linked by disulfide bonds.
- Product Link
- http://www.bethyl.com/product/A303-712A
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