Rabbit anti-Itch Antibody, Affinity Purified
Brand:
A301-992A-M
- Brand
- Bethyl Laboratories
- Application
- IP
WB
- Storage Conditions
- 2 - 8° C
- Host
- Rabbit
- Conjugation
- Unconjugated
- Immunogen
- between 650 and 700
- Buffer
- Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
- Reactivity
- Human
- Target
- Itch
- Shelf Life
- 1 year from date of receipt
- Antibody Type
- Polyclonal
- Alternate Names
- ADMFD, AIF4, AIP4, atrophin-1 interacting protein 4, Atrophin-1-interacting protein 4, E3 ubiquitin-protein ligase Itchy homolog, HECT-type E3 ubiquitin transferase Itchy homolog, Itch, itchy E3 ubiquitin protein ligase homolog, NAPP1, NFE2-associated polypeptide 1
- Format
- Whole IgG
- Presumed Reactivity
- Based on 100% sequence identity, this antibody is predicted to react with Mouse
- Product Type
- Primary Antibodies
- Product Sub Types
- Primary Antibodies
- UNSPSC
- 12352203
- Western Blot (WB)
- 1:2,000 - 1:10,000
- Immunoprecipitation (IP)
- Not recommended
- Target Sentence
- Itch is an HECT-type E3 ubiquitin ligase that promotes the ubiquitination of Notch. The drosophila ortholog of Itch, suppressor of deltex (SU(DX)), was originally identified as a negative regulator of the Notch pathway. Deltex is a transmembrane ligand for Notch and also has a mammalian homolog, DTX1.The human ortholog of Itch and (SU(DX)) is called AIP4 (atrophin-1-interacting protein) and was first described as a protein that interacts with the product of the gene responsible for dentatorubral and pallidoluysian atrophy (DRPLA). In mice, Itch was identified as a mutant locus in 18H mice that resulted in a fatal disease characterized by inflammation of the skin which resulted in constant itching and scarring.
- Product Link
- http://www.bethyl.com/product/A301-992A
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