Rabbit anti-Kaiso Antibody, Affinity Purified
Brand:
A303-558A-M
- Brand
- Bethyl Laboratories
- Application
- IP
WB
- Storage Conditions
- 2 - 8° C
- Host
- Rabbit
- Conjugation
- Unconjugated
- Immunogen
- between 622 and 672
- Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
- Reactivity
- Human
- Target
- Kaiso
- Shelf Life
- 1 year from date of receipt
- Antibody Type
- Polyclonal
- Alternate Names
- kaiso transcription factor, transcriptional regulator Kaiso, WUGSC:H_DJ525N14.1, zinc finger and BTB domain-containing protein 33, ZNF348, ZNF-kaiso
- Format
- Whole IgG
- Presumed Reactivity
- Based on 100% sequence identity, this antibody is predicted to react with Mouse
- Product Type
- Primary Antibodies
- Product Sub Types
- Primary Antibodies
- UNSPSC
- 12352203
- Western Blot (WB)
- 1:2,000 - 1:10,000
- Immunoprecipitation (IP)
- 2 - 10 µg/mg lysate
- Target Sentence
- Transcriptional regulator Kaiso possesses bimodal DNA-binding specificity and binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. Kaiso contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. Kaiso may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. [taken from NCBI Entrez Gene (Gene ID: 10009)].
- Product Link
- http://www.bethyl.com/product/A303-558A
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