Rabbit anti-Mel-18 Antibody, Affinity Purified
Brand:
A303-580A-M
- Brand
- Bethyl Laboratories
- Application
- IP
WB
- Storage Conditions
- 2 - 8° C
- Host
- Rabbit
- Conjugation
- Unconjugated
- Immunogen
- between 125 and 175
- Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
- Reactivity
- Human
- Target
- Mel-18
- Shelf Life
- 1 year from date of receipt
- Antibody Type
- Polyclonal
- Alternate Names
- DNA-binding protein Mel-18, MEL-18, polycomb group RING finger protein 2, ring finger protein 110, RNF110, zinc finger protein 144, ZNF144
- Format
- Whole IgG
- Product Type
- Primary Antibodies
- Product Sub Types
- Primary Antibodies
- UNSPSC
- 12352203
- Western Blot (WB)
- 1:2,000 - 1:10,000
- Immunoprecipitation (IP)
- Not recommended
- Target Sentence
- Mel18 is a transcriptional repressor and binds specifically to the DNA sequence 5'-GACTNGACT-3'. Mel-18 is a component of a polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. Mel-18 has tumor suppressor activity. Mel-18 plays a role in control of cell proliferation and/or neural cell development, and also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ P35227].
- Product Link
- http://www.bethyl.com/product/A303-580A
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