Rabbit anti-MGRN1 Antibody, Affinity Purified
Brand:
A302-913A-T
- Brand
- Bethyl Laboratories
- Application
- IP
- Storage Conditions
- 2 - 8° C
- Host
- Rabbit
- Conjugation
- Unconjugated
- Immunogen
- between 505 and 555
- Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
- Reactivity
- Human
- Target
- MGRN1
- Shelf Life
- 1 year from date of receipt
- Antibody Type
- Polyclonal
- Alternate Names
- E3 ubiquitin-protein ligase MGRN1, mahogunin ring finger 1, E3 ubiquitin protein ligase, mahogunin RING finger protein 1, probable E3 ubiquitin-protein ligase MGRN1, RING finger protein 156, RING-type E3 ubiquitin transferase MGRN1, RNF156
- Format
- Whole IgG
- Product Type
- Primary Antibodies
- Product Sub Types
- Primary Antibodies
- UNSPSC
- 12352203
- Western Blot (WB)
- Not recommended
- Immunoprecipitation (IP)
- 2 - 5 µg/mg lysate
- Target Sentence
- MGRN1 (mahogunin RING finger protein 1) is an E3 ubiquitin-protein ligase that mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. MGRN1 plays a role in the regulation of endosome-to-lysosome trafficking. It impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production but does not promote MC1R ubiquitination [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ O60291].
- Product Link
- http://www.bethyl.com/product/A302-913A-T
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