Rabbit anti-NEDD4L IHC Antibody, Affinity Purified
Brand:
IHC-00713-T
- Brand
- Bethyl Laboratories
- Application
- IHC
- Storage Conditions
- 2 - 8° C
- Host
- Rabbit
- Conjugation
- Unconjugated
- Immunogen
- Between 275 and 325
- Buffer
- Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
- Reactivity
- Human, Mouse
- Target
- NEDD4L
- Shelf Life
- 1 year from date of receipt
- Antibody Type
- Polyclonal
- Alternate Names
- E3 ubiquitin-protein ligase NEDD4-like, HECT-type E3 ubiquitin transferase NED4L, hNEDD4-2, NEDD4.2, NEDD4-2, PVNH7, RSP5, ubiquitin-protein ligase Rsp5
- Format
- Whole IgG
- Product Type
- Primary Antibodies
- Product Sub Types
- Primary Antibodies
- UNSPSC
- 12352203
- Immunohistochemistry (IHC)
- 1:100 - 1:500
- Target Sentence
- NEDD4L (neural precursor cell expressed, developmentally down-regulated 4-like) functions as an E3 ubiquitin-protein ligase. NEDD4L inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. It also promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5 [taken from the Universal Protein Resource (UniProt) wwwuniprotorg/uniprot/Q96PU5].
- Product Link
- http://www.bethyl.com/product/IHC-00713-T
Related products
