Rabbit anti-p600 Antibody, Affinity Purified
Brand:
A302-277A-T
- Brand
- Bethyl Laboratories
- Application
- IHC
IP
- Storage Conditions
- 2 - 8° C
- Host
- Rabbit
- Conjugation
- Unconjugated
- Immunogen
- between 150 and 200
- Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
- Reactivity
- Human
- Target
- p600
- Shelf Life
- 1 year from date of receipt
- Antibody Type
- Polyclonal
- Alternate Names
- 600 kDa retinoblastoma protein-associated factor, E3 ubiquitin-protein ligase UBR4, N-recognin-4, p600, RBAF600, retinoblastoma-associated factor 600-like protein, retinoblastoma-associated factor of 600 kDa, RING-type E3 ubiquitin transferase UBR4, zinc finger UBR1-type protein 1, ZUBR1
- Format
- Whole IgG
- Presumed Reactivity
- Based on 100% sequence identity, this antibody is predicted to react with Mouse and Rat
- Product Type
- Primary Antibodies
- Product Sub Types
- Primary Antibodies
- UNSPSC
- 12352203
- Western Blot (WB)
- Not recommended. Use rabbit anti-p600 antibody A302-278A or A302-279A.
- Immunoprecipitation (IP)
- 10 µg/mg lysate
- Immunohistochemistry (IHC)
- 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
- Target Sentence
- p600 is an E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. It recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, p600 forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Additionally p600 regulates integrin-mediated signaling and may play a role in activation of FAK in response to cell-matrix interactions [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q5T4S7].
- Product Link
- http://www.bethyl.com/product/A302-277A
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