![Rabbit anti-PBRM1 Recombinant Monoclonal Antibody [BL-39-2C3]](https://www.axilscientific.com/10695-superlarge_default/rabbit-anti-pbrm1-recombinant-monoclonal-antibody-bl-39-2c3-.jpg)
Rabbit anti-PBRM1 Recombinant Monoclonal Antibody [BL-39-2C3]
Brand:
A700-019-T
- Brand
- Bethyl Laboratories
- Application
- F
ICC
IHC
IHC-IF
IP
WB
- Storage Conditions
- 2 - 8° C
- Host
- Rabbit
- Conjugation
- Unconjugated
- Immunogen
- residues 1-293
- Buffer
- Borate Buffered Saline (BBS) pH 8.2 with 0.1% BSA and 0.09% Sodium Azide
- Reactivity
- Human, Mouse
- Target
- PBRM1
- Shelf Life
- 1 year from date of receipt
- Antibody Type
- Recombinant Monoclonal
- Alternate Names
- BAF180, BRG1-associated factor 180, hPB1, PB1, polybromo-1D, protein polybromo-1
- Format
- Whole IgG
- Product Type
- Primary Antibodies
- Product Sub Types
- Primary Antibodies
- UNSPSC
- 12352203
- Western Blot (WB)
- 1:1000
- Immunoprecipitation (IP)
- 5 µl/mg lysate
- Immunohistochemistry (IHC)
- 1:100 - 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
- Immunocytochemistry (ICC)
- 1:100 - 1:500. Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE cell sections.
- Immunohistochemistry-Immunofluoresence (IHC-IF)
- 1:100 - 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
- Flow Cytometry (F)
- Fixed and permeabilized cells were stained with 0.8 µl per 1 x 10^6 cells.
- Target Sentence
- The SMARCs (SWI/SNF-related, matrix-associated, actin-dependent regulators of chromatin), and BAFs (BRG1-associated factors), have been identified as components of the mammalian SWI/SNF-like chromatin-remodeling protein complexes. These multi-protein complexes are proposed to function as ATP-driven motors that translocate along DNA and destabilize nucleosomal structures to facilitate transcription factor binding. PBRM1 is a component of the SWI/SNF-B (PBAF) complex. It contains six bromodomains which are defined by a 110 amino-acid module that interacts with acetylated lysine and is found in many chromatin binding proteins and histone acetyltransferases. PBRM1 has been proposed to function as a tumor suppressor protein. Recently, PBRM1 has been found to play a role in mediating cell cycle arrest in response to DNA damage via the regulation of the tumor suppressor p21.
- Product Link
- http://www.bethyl.com/product/A700-019