Rabbit anti-Plexin-A3 Antibody, Affinity Purified
Brand:
A304-473A-M
- Brand
- Bethyl Laboratories
- Application
- IP
WB
- Storage Conditions
- 2 - 8° C
- Host
- Rabbit
- Conjugation
- Unconjugated
- Immunogen
- between 1050 and 1100
- Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
- Reactivity
- Human
- Target
- Plexin-A3
- Shelf Life
- 1 year from date of receipt
- Antibody Type
- Polyclonal
- Alternate Names
- 6.3, HSSEXGENE, plexin-4, plexin-A3, PLXN3, PLXN4, semaphorin receptor SEX, Sex chromosome X transmembrane protein of HGF receptor family 3, XAP-6
- Format
- Whole IgG
- Product Type
- Primary Antibodies
- Product Sub Types
- Primary Antibodies
- UNSPSC
- 12352203
- Western Blot (WB)
- 1:2,000 - 1:10,000
- Immunoprecipitation (IP)
- 2 - 10 µg/mg lysate
- Target Sentence
- Plexin-A3 is a coreceptor for SEMA3A and SEMA3F. It is necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plexin-A3 plays a role in axon guidance in the developing nervous system. It regulates the migration of sympathetic neurons, but not of neural crest precursors. Plexin-A3 is required for normal dendrite spine morphology in pyramidal neurons. It may play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P51805].
- Product Link
- http://www.bethyl.com/product/A304-473A
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