Rabbit anti-PSMB8/LMP7 Antibody, Affinity Purified
Brand:
A305-229A-M
- Brand
- Bethyl Laboratories
- Application
- IP
WB
- Storage Conditions
- 2 - 8° C
- Host
- Rabbit
- Conjugation
- Unconjugated
- Immunogen
- between 125 and 175
- Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
- Reactivity
- Human
- Target
- PSMB8/LMP7
- Shelf Life
- 1 year from date of receipt
- Antibody Type
- Polyclonal
- Alternate Names
- ALDD, D6S216, D6S216E, JMP, LMP7, low molecular mass protein 7, low molecular weight protein 7, macropain subunit C13, multicatalytic endopeptidase complex subunit C13, NKJO, PRAAS1, protease component C13, proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7), proteasome catalytic subunit 3i, proteasome component C13, proteasome subunit beta 5i, proteasome subunit beta type-8, Proteasome subunit beta-5i, proteasome subunit Y2, proteasome-related gene 7, PSMB5i, really interesting new gene 10 protein, RING10
- Format
- Whole IgG
- Presumed Reactivity
- Based on 100% sequence identity, this antibody is predicted to react with Mouse, Rat, Bovine and Dog
- Product Type
- Primary Antibodies
- Product Sub Types
- Primary Antibodies
- UNSPSC
- 12352203
- Western Blot (WB)
- 1:1,000 - 1:5,000
- Immunoprecipitation (IP)
- Not recommended
- Target Sentence
- Proteasomes are distributed throughout eukaryotic cells and cleave peptides in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The gene PSMB8 (aka LMP7) encodes a member of the proteasome B-type family, proteasome subunit beta type-8, that is a 20S core beta subunit. Expression of PSMB8/LMP7 is induced by gamma interferon and the PSMB8 gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Nakajo syndrome, an autosomal recessive autoinflammatory disorder, is caused by mutations to PSMB8 [taken from NCBI Entrez Gene (Gene ID: 5696) and UniProtKB (Entry: P28062)].
- Product Link
- http://www.bethyl.com/product/A305-229A
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