Rabbit anti-PTPN11/Shp2 Antibody, Affinity Purified
Brand:
A301-544A-M
- Brand
- Bethyl Laboratories
- Application
- IP
WB
- Storage Conditions
- 2 - 8° C
- Host
- Rabbit
- Conjugation
- Unconjugated
- Immunogen
- between 543 and 593
- Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
- Reactivity
- Human, Mouse
- Target
- PTPN11/Shp2
- Shelf Life
- 1 year from date of receipt
- Antibody Type
- Polyclonal
- Alternate Names
- BPTP3, CFC, JMML, METCDS, NS1, protein-tyrosine phosphatase 1D, protein-tyrosine phosphatase 2C, PTP-1D, PTP2C, PTP-2C, SHP2, SHP-2, SH-PTP2, SH-PTP3, tyrosine-protein phosphatase non-receptor type 11
- Format
- Whole IgG
- Presumed Reactivity
- Based on 100% sequence identity, this antibody is predicted to react with Chicken
- Product Type
- Primary Antibodies
- Product Sub Types
- Primary Antibodies
- UNSPSC
- 12352203
- Western Blot (WB)
- 1:2,000 - 1:10,000
- Immunoprecipitation (IP)
- 2 - 5 µg/mg lysate
- Target Sentence
- PTPN11/Shp2 is a src-homology 2-containing protein-tyrosine phosphatase (PTP). PTPN11/Shp2 is a non-receptor phosphatase that mediates a variety of cytokine, growth factor, and hormone signals. Signal transduction by PTPN11/Shp2 is achieved via the activation of the Ras/mitogen-activated protein kinase pathway. Heterogenous gain of function mutations in PTPN11/Shp2 are associated with juvenile myelomonocytic leukemia (JMML) and Noonan syndrome, a disorder characterized by short stature, facial dysmorphology, and congenital heart defects.
- Product Link
- http://www.bethyl.com/product/A301-544A
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