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Rabbit anti-RUNX3 Recombinant Monoclonal Antibody [BLR122H]
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Brand:
A700-122-T
- Brand
- Bethyl Laboratories
- Application
- F
ICC
IHC
IP
WB
- Storage Conditions
- 2 - 8° C
- Host
- Rabbit
- Conjugation
- Unconjugated
- Immunogen
- between 1 and 50
- Buffer
- Borate Buffered Saline (BBS) pH 8.2 with 0.1% BSA and 0.09% Sodium Azide
- Reactivity
- Human
- Target
- RUNX3
- Shelf Life
- 1 year from date of receipt
- Antibody Type
- Recombinant Monoclonal
- Alternate Names
- acute myeloid leukemia 2 protein, acute myeloid leukemia gene 2, AML2, CBFA3, CBF-alpha-3, core-binding factor subunit alpha-3, core-binding factor, runt domain, alpha subunit 3, oncogene AML-2, PEA2 alpha C, PEA2-alpha C, PEBP2 alpha C, PEBP2aC, PEBP2-alpha C, polyomavirus enhancer-binding protein 2 alpha C subunit, runt-related transcription factor 3, SL3/AKV core-binding factor alpha C subunit, SL3-3 enhancer factor 1 alpha C subunit, transcription factor AML2
- Format
- Whole IgG
- Product Type
- Primary Antibodies
- Product Sub Types
- Primary Antibodies
- UNSPSC
- 12352203
- Western Blot (WB)
- 1:1,000
- Immunoprecipitation (IP)
- 20 µl/1 mg lysate
- Immunohistochemistry (IHC)
- 1:100 to 1:500. Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE tissue sections.
- Immunocytochemistry (ICC)
- 1:100 to 1:500. Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE cell sections.
- Flow Cytometry (F)
- Fixed in 4% formaldehyde and permeabilized with 90% methanol. 1 µl per 1 x 10^6 cells.
- Target Sentence
- RUNX3 is a member of the runt domain-containing family of transcription factors. A heterodimer of RUNX3 and CBFB forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters. This complex binding can either activate or suppress transcription to control cellular proliferation and/or differentiation, in particular cytotoxic T cell differentiation. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q13761].
- Product Link
- http://www.bethyl.com/product/A700-122
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