Rabbit anti-SHARP Antibody, Affinity Purified
Brand:
A301-119A-T
- Brand
- Bethyl Laboratories
- Application
- IP
- Storage Conditions
- 2 - 8° C
- Host
- Rabbit
- Conjugation
- Unconjugated
- Immunogen
- between 1350 and 1400
- Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
- Reactivity
- Human
- Target
- SHARP
- Shelf Life
- 1 year from date of receipt
- Antibody Type
- Polyclonal
- Alternate Names
- HIAA0929, MINT, Msx2 interacting nuclear target (MINT) homolog, msx2-interacting protein, nuclear receptor transcription cofactor, RBM15C, SHARP, SMART/HDAC1-associated repressor protein, SPEN homolog, spen homolog, transcriptional regulator
- Format
- Whole IgG
- Presumed Reactivity
- Based on 100% sequence identity, this antibody is predicted to react with Mouse
- Product Type
- Primary Antibodies
- Product Sub Types
- Primary Antibodies
- UNSPSC
- 12352203
- Western Blot (WB)
- Not recommended for crude preparations. A301-119A can be used successfully for WB of enriched preparations (e.g. immunoprecipitated) SHARP.
- Immunoprecipitation (IP)
- 2 - 10 µg/mg lysate
- Target Sentence
- SHARP functions as a transcriptional repressor by interacting with proteins involved in deacetylation such as the NuRD (nucleosome remodeling) complex. SHARP can also repress transcription by interacting with corepressors such as SMRT/NCoR (silencing mediator for retinoid and thyroid receptors/nuclear receptor corepressor). SHARP is able to suppress transcription through the Notch/RBP-J signaling pathway by competing RBP-J binding with the intracellular domain of Notch.
- Product Link
- http://www.bethyl.com/product/A301-119A
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