Rabbit anti-SLBP Antibody, Affinity Purified
Brand:
A303-968A-M
- Brand
- Bethyl Laboratories
- Application
- IP
WB
- Storage Conditions
- 2 - 8° C
- Host
- Rabbit
- Conjugation
- Unconjugated
- Immunogen
- Between 220 and 270
- Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
- Reactivity
- Human
- Target
- SLBP
- Shelf Life
- 1 year from date of receipt
- Antibody Type
- Polyclonal
- Alternate Names
- hairpin binding protein, histone, HBP, histone binding protein, histone RNA hairpin-binding protein, histone stem-loop binding protein, Histone stem-loop-binding protein, stem-loop (histone) binding protein
- Format
- Whole IgG
- Product Type
- Primary Antibodies
- Product Sub Types
- Primary Antibodies
- UNSPSC
- 12352203
- Western Blot (WB)
- 1:1,000 - 1:5,000
- Immunoprecipitation (IP)
- 2 - 10 µg/mg lysate
- Target Sentence
- Stem-loop-binding protein (SLBP) is an RNA-binding protein involved in the histone pre-mRNA processing. SLBP binds the stem-loop structure of replication-dependent histone pre-mRNAs and contributes to efficient 3'-end processing by stabilizing the complex between histone pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP), via the histone downstream element (HDE). SLBP plays an important role in targeting mature histone mRNA from the nucleus to the cytoplasm and to the translation machinery. It stabilizes mature histone mRNA and could be involved in cell-cycle regulation of histone gene expression. It is also involved in the mechanism by which growing oocytes accumulate histone proteins that support early embryogenesis. SLBP binds to the 5' side of the stem-loop structure of histone pre-mRNAs [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q14493].
- Product Link
- http://www.bethyl.com/product/A303-968A
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