Rabbit anti-TDP2 Antibody, Affinity Purified
Brand:
A302-737A-M
- Brand
- Bethyl Laboratories
- Application
- IHC
IP
WB
- Storage Conditions
- 2 - 8° C
- Host
- Rabbit
- Conjugation
- Unconjugated
- Immunogen
- between 50 and 100
- Buffer
- Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
- Reactivity
- Human
- Target
- TDP2
- Shelf Life
- 1 year from date of receipt
- Antibody Type
- Polyclonal
- Alternate Names
- 5'-Tyr-DNA phosphodiesterase, 5'-tyrosyl-DNA phosphodiesterase, AD022, dJ30M3.3, EAP2, EAPII, epididymis secretory sperm binding protein, ETS1-associated protein 2, ETS1-associated protein II, hTDP2, TRAF and TNF receptor-associated protein, TTRAP, tyr-DNA phosphodiesterase 2, tyrosyl-DNA phosphodiesterase 2, tyrosyl-RNA phosphodiesterase, VPg unlinkase
- Format
- Whole IgG
- Product Type
- Primary Antibodies
- Product Sub Types
- Primary Antibodies
- UNSPSC
- 12352203
- Western Blot (WB)
- 1:2,000 - 1:10,000
- Immunoprecipitation (IP)
- 2 - 5 µg/mg lysate
- Immunohistochemistry (IHC)
- 1:100 - 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
- Target Sentence
- TDP2 (5’-Tyr-DNA phosphodiesterase 2) is also known as TTRAP (TRAF and TNF receptor-associated protein). TTRAP is a DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. It catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. TTRAP also hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. TTRAP may also act as a negative regulator of ETS1 and may inhibit nuclear factor-kappa-B activation [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O95551].
- Product Link
- http://www.bethyl.com/product/A302-737A
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