Rabbit anti-UPF3B Antibody, Affinity Purified
Brand:
A303-689A-T
- Brand
- Bethyl Laboratories
- Application
- IP
- Storage Conditions
- 2 - 8° C
- Host
- Rabbit
- Conjugation
- Unconjugated
- Immunogen
- Between 433 and 483
- Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
- Reactivity
- Human
- Target
- UPF3B
- Shelf Life
- 1 year from date of receipt
- Antibody Type
- Polyclonal
- Alternate Names
- HUPF3B, hUpf3p-X, mental retardation, X-linked 62, MRX62, MRXS14, nonsense mRNA reducing factor 3B, regulator of nonsense transcripts 3B, RENT3B, UPF3 regulator of nonsense transcripts homolog B, UPF3B pseudogene 1, UPF3B pseudogene 2, UPF3B pseudogene 3, UPF3BP1, UPF3BP2, UPF3BP3, Upf3p-X, UPF3X, up-frameshift suppressor 3 homolog B, up-frameshift suppressor 3 homolog on chromosome X
- Format
- Whole IgG
- Product Type
- Primary Antibodies
- Product Sub Types
- Primary Antibodies
- UNSPSC
- 12352203
- Western Blot (WB)
- Not recommended
- Immunoprecipitation (IP)
- 2 - 10 µg/mg lysate
- Target Sentence
- UPF3B (UPF regulator of nonsense transcripts homolog B) is involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. UPF3B recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2, UPF3B stimulates both ATPase and RNA helicase activities of UPF1 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q9BZI7].
- Product Link
- http://www.bethyl.com/product/A303-689A
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