Rabbit anti-WWOX Antibody, Affinity Purified
Brand:
A304-079A-T
- Brand
- Bethyl Laboratories
- Application
- IHC
IP
- Storage Conditions
- 2 - 8° C
- Host
- Rabbit
- Conjugation
- Unconjugated
- Immunogen
- Between 364 and 414
- Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
- Reactivity
- Human
- Target
- WWOX
- Shelf Life
- 1 year from date of receipt
- Antibody Type
- Polyclonal
- Alternate Names
- D16S432E, EIEE28, FOR, FRA16D, fragile site FRA16D oxidoreductase, HHCMA56, PRO0128, SCAR12, SDR41C1, short chain dehydrogenase/reductase family 41C member 1, WOX1, WW domain-containing oxidoreductase, WW domain-containing protein WWOX
- Format
- Whole IgG
- Presumed Reactivity
- Based on 100% sequence identity, this antibody is predicted to react with Orangutan
- Product Type
- Primary Antibodies
- Product Sub Types
- Primary Antibodies
- UNSPSC
- 12352203
- Western Blot (WB)
- Not recommended. A304-079A-T has not performed satisfactorily when used for WB of WWOX in crude preparations (e.g. whole cell lysate). This antibody can be used for WB of enriched (e.g. immunoprecipitated) sources of WWOX.
- Immunoprecipitation (IP)
- 2 - 10 µg/mg lysate
- Immunohistochemistry (IHC)
- 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
- Target Sentence
- WW domain-containing oxidoreductase (WWOX) is a putative oxidoreductase, acts as a tumor suppressor, plays a role in apoptosis, and is required for normal bone development (by similarity). WWOX may function synergistically with p53/TP53 to control genotoxic stress-induced cell death. It plays a role in TGFB1 signaling and TGFB1-mediated cell death and may also play a role in tumor necrosis factor (TNF)-mediated cell death. WWOX inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9NZC7].
- Product Link
- http://www.bethyl.com/product/A304-079A-T
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