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Mouse anti-CD45RO Monoclonal Antibody, Purified [UCHL-1]
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Brand:
A500-020A-T
- Brand
- Bethyl Laboratories
- Application
- ICC
IHC
IHC-IF
WB
mIF
- Storage Conditions
- 2 - 8° C
- Host
- Mouse
- Conjugation
- Unconjugated
- Immunogen
- Cultured T-cells from an IL-2-dependent T-cell line (CA1)
- Buffer
- Phosphate Buffered Saline (PBS) containing 0.09% Sodium Azide
- Reactivity
- Human
- Target
- CD45RO
- Shelf Life
- 1 year from date of receipt
- Antibody Type
- Monoclonal
- Alternate Names
- B220, CD antigen CD45, CD45, CD45 antigen, CD45R, GP180, LCA, L-CA, Leukocyte common antigen, LY5, protein tyrosine phosphatase, receptor type, c polypeptide, receptor-type tyrosine-protein phosphatase C, T200, T200 glycoprotein, T200 leukocyte common antigen
- Format
- Whole IgG
- Product Type
- Primary Antibodies
- Product Sub Types
- Primary Antibodies
- UNSPSC
- 12352203
- Western Blot (WB)
- 1:250
- Immunohistochemistry (IHC)
- 1:100 - 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
- Immunocytochemistry (ICC)
- 1:100 - 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE cell sections.
- Immunohistochemistry-Immunofluoresence (IHC-IF)
- 1:100 to 1:500. Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE tissue sections.
- Target Sentence
- CD45RO is also known as protein tyrosine phosphatase receptor type C (PTPRC). It is a protein tyrosine phosphatase required for T-cell activation through the antigen receptor. CD45RO acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, CD45RO recruits and dephosphorylates SKAP1 and FYN. It also dephosphorylates LYN, and thereby modulates LYN activity (By similarity)[taken from UniProtKB (Entry: P08575)].
- Product Link
- http://www.bethyl.com/product/A500-020A
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