Rabbit anti-DDX3 Antibody, Affinity Purified
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Brand:
A300-476A-M
- Brand
- Bethyl Laboratories
- Application
- IP
WB
- Storage Conditions
- 2 - 8° C
- Host
- Rabbit
- Conjugation
- Unconjugated
- Immunogen
- between 600 and C-term
- Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
- Reactivity
- Human
- Target
- DDX3
- Shelf Life
- 1 year from date of receipt
- Antibody Type
- Polyclonal
- Alternate Names
- ATP-dependent RNA helicase DDX3X, CAP-Rf, DBX, DDX14, DDX3, DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked, DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked, DEAD box protein 3, X-chromosomal, DEAD box, X isoform, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, DEAD/H box-3, helicase-like protein 2, HLP2, MRX102
- Format
- Whole IgG
- Presumed Reactivity
- Based on 100% sequence identity, this antibody is predicted to react with Mouse, Orangutan and Chimpanzee
- Product Type
- Primary Antibodies
- Product Sub Types
- Primary Antibodies
- UNSPSC
- 12352203
- Western Blot (WB)
- 1:5,000 - 1:15,000
- Immunoprecipitation (IP)
- 2 - 5 µg/mg lysate
- Target Sentence
- DDX3 is a member of the DEAD box family of proteins that possesses several conserved motifs which include the highly conserved DEAD (Asp-Glu-Ala-Asp) amino acid sequence motif. The major activity of DEAD box proteins is to function as ATP-dependent RNA helicases. As helicases, DEAD proteins play an important role in all aspects of RNA metabolism and function which include pre-mRNA splicing, RNA synthesis, RNA degradation, RNA export, RNA translation, RNA secondary structure formation, ribosome biogenesis, and the assembly of RNP complexes. DDX3 exhibits a variety of functions. DDX3 is a candidate tumor suppressor that suppresses tumor growth and transcriptionally activates the p21 promoter. DDX3 has been shown to play a role in translation as an eIF4E inhibitory protein that regulates translation initiation. These findings, as well as the observation that DDX3 is regulated by hepatitis C virus and is down-regulated in hepatocellular carcinoma, suggest an important role for DDX3 in growth-regulatory functions.
- Product Link
- http://www.bethyl.com/product/A300-476A
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