Rabbit anti-LYN Antibody, Affinity Purified
Brand:
A302-683A-M
- Brand
- Bethyl Laboratories
- Application
- IP
WB
- Storage Conditions
- 2 - 8° C
- Host
- Rabbit
- Conjugation
- Unconjugated
- Immunogen
- between 1 and 50
- Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
- Reactivity
- Human
- Target
- LYN
- Shelf Life
- 1 year from date of receipt
- Antibody Type
- Polyclonal
- Alternate Names
- JTK8, lck/Yes-related novel protein tyrosine kinase, p53Lyn, p56Lyn, tyrosine-protein kinase Lyn, v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
- Format
- Whole IgG
- Presumed Reactivity
- Based on 100% sequence identity, this antibody is predicted to react with Rat
- Product Type
- Primary Antibodies
- Product Sub Types
- Primary Antibodies
- UNSPSC
- 12352203
- Western Blot (WB)
- 1:2,000 - 1:10,000
- Immunoprecipitation (IP)
- 5 - 15 µg/mg lysate
- Target Sentence
- LYN is a tyrosine protein kinase that acts as an effector of EpoR (erythropoietin receptor) in controlling KIT expression and may play a central role in erythroid differentiation during the switch between proliferation and maturation. LYN acts as the mediator that relays suppressing signals from the chemokine receptor CXCR4 to beta-2 integrin LFA-1 in hematopoietic precursors. It is involved in induction of stress-activated protein kinase (SAPK), but not ERK or p38 MAPK, in response to genotoxic agents. LYN induces SAPK by a MKK7- and MEKK1-dependent mechanism [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P07948].
- Product Link
- http://www.bethyl.com/product/A302-683A
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