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Rabbit anti-PD-L1 Recombinant Monoclonal Antibody [BLR020E]
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Brand:
A700-020-T
- Brand
- Bethyl Laboratories
- Application
- ICC-IF
IHC
IHC-IF
IP
WB
mIF
- Storage Conditions
- 2 - 8° C
- Host
- Rabbit
- Conjugation
- Unconjugated
- Immunogen
- between 250 to 290 (C-term)
- Buffer
- Borate Buffered Saline (BBS) pH 8.2 with 0.1% BSA and 0.09% Sodium Azide
- Reactivity
- Human
- Target
- PD-L1
- Shelf Life
- 1 year from date of receipt
- Antibody Type
- Recombinant Monoclonal
- Alternate Names
- B7 homolog 1, B7-H, B7H1, B7-H1, CD antigen CD274, CD274 antigen, PDCD1 ligand 1, PDCD1L1, PDCD1LG1, PDL1, PD-L1, programmed cell death 1 ligand 1, Programmed death ligand 1
- Format
- Whole IgG
- Product Type
- Primary Antibodies
- Product Sub Types
- Primary Antibodies
- UNSPSC
- 12352203
- Western Blot (WB)
- 1:1000
- Immunoprecipitation (IP)
- 20 µl/mg lysate
- Immunohistochemistry (IHC)
- 1:100 - 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
- Immunohistochemistry-Immunofluoresence (IHC-IF)
- 1:100 - 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
- Immunocytochemistry-Immunofluoresence (ICC-IF)
- 1:100 - 1:500. Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE cell sections.
- Target Sentence
- PD-L1 is an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. PD-L1 is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma [taken from NCBI Entrez Gene (Gene ID: 55193)].
- Product Link
- http://www.bethyl.com/product/A700-020
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