Rabbit anti-RIP3 Antibody, Affinity Purified
Brand:
A304-378A-M
- Brand
- Bethyl Laboratories
- Application
- IP
WB
- Storage Conditions
- 2 - 8° C
- Host
- Rabbit
- Conjugation
- Unconjugated
- Immunogen
- between 400 and 450
- Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
- Reactivity
- Human
- Target
- RIP3
- Shelf Life
- 1 year from date of receipt
- Antibody Type
- Polyclonal
- Alternate Names
- receptor interacting protein 3, Receptor-interacting protein 3, receptor-interacting serine/threonine-protein kinase 3, RIP3, RIP-3, RIP-like protein kinase 3
- Format
- Whole IgG
- Product Type
- Primary Antibodies
- Product Sub Types
- Primary Antibodies
- UNSPSC
- 12352203
- Western Blot (WB)
- 1:2,000 - 1:10,000
- Immunoprecipitation (IP)
- 2 - 10 µg/mg lysate
- Target Sentence
- Receptor-interacting serine/threonine-protein kinase 3 (RIP3) is essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIP3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIP3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y572].
- Product Link
- http://www.bethyl.com/product/A304-378A
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