Rabbit anti-Sprouty 2 Antibody, Affinity Purified
Brand:
A303-535A-T
- Brand
- Bethyl Laboratories
- Application
- IP
- Storage Conditions
- 2 - 8° C
- Host
- Rabbit
- Conjugation
- Unconjugated
- Immunogen
- between 265 and 315
- Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
- Reactivity
- Human
- Target
- Sprouty 2
- Shelf Life
- 1 year from date of receipt
- Antibody Type
- Polyclonal
- Alternate Names
- hSPRY2, IGAN3, protein sprouty homolog 2, Spry-2
- Format
- Whole IgG
- Presumed Reactivity
- Based on 100% sequence identity, this antibody is predicted to react with Mouse and Bovine
- Product Type
- Primary Antibodies
- Product Sub Types
- Primary Antibodies
- UNSPSC
- 12352203
- Western Blot (WB)
- Not recommended. A303-535A has not performed satisfactorily when used for WB of Sprouty 2 in crude preparations (e.g. whole cell lysate). This antibody can be used for WB of enriched (e.g. immunoprecipitated) sources of Sprouty 2.
- Immunoprecipitation (IP)
- 2 - 10 µg/mg lysate
- Target Sentence
- Sprouty 2 contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells sprouty 2 is transiently upregulated in response to fibroblast growth factor two. Sprouty 2 is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. Sprouty 2 interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. Sprouty 2 may play a role in alveoli branching during lung development as shown by a similar mouse protein [taken from NCBI Entrez Gene (Gene ID: 10253)].
- Product Link
- http://www.bethyl.com/product/A303-535A
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