Rabbit anti-SuFu Antibody, Affinity Purified
Brand:
A302-335A-M
- Brand
- Bethyl Laboratories
- Application
- IP
WB
- Storage Conditions
- 2 - 8° C
- Host
- Rabbit
- Conjugation
- Unconjugated
- Immunogen
- between 434 and 484
- Buffer
- Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
- Reactivity
- Human, Mouse
- Target
- SuFu
- Shelf Life
- 1 year from date of receipt
- Antibody Type
- Polyclonal
- Alternate Names
- JBTS32, PRO1280, SUFUH, SUFUXL, suppressor of fused homolog
- Format
- Whole IgG
- Product Type
- Primary Antibodies
- Product Sub Types
- Primary Antibodies
- UNSPSC
- 12352203
- Western Blot (WB)
- 1:2,000 - 1:10,000
- Immunoprecipitation (IP)
- 2 - 5 µg/mg lysate
- Target Sentence
- Suppressor of fused (SuFu) is a negative regulator of the hedgehog and beta-catenin signaling pathway. It down-regulates GLI1-mediated transactivation of target genes and is part of a corepressor complex that acts on DNA-bound GLI1. SuFu may also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Additionally, SuFu sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9UMX1].
- Product Link
- http://www.bethyl.com/product/A302-335A
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