Rabbit anti-UFD1 Antibody, Affinity Purified
Brand:
A301-876A-M
- Brand
- Bethyl Laboratories
- Application
- IP
WB
- Storage Conditions
- 2 - 8° C
- Host
- Rabbit
- Conjugation
- Unconjugated
- Immunogen
- between 257 and 307
- Buffer
- Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
- Reactivity
- Human
- Target
- UFD1
- Shelf Life
- 1 year from date of receipt
- Antibody Type
- Polyclonal
- Alternate Names
- UB fusion protein 1, ubiquitin fusion degradation 1 like, Ubiquitin fusion degradation protein 1, ubiquitin fusion degradation protein 1 homolog, ubiquitin recognition factor in ER-associated degradation protein 1, UFD1L
- Format
- Whole IgG
- Presumed Reactivity
- Based on 100% sequence identity, this antibody is predicted to react with Mouse and Rat
- Product Type
- Primary Antibodies
- Product Sub Types
- Primary Antibodies
- UNSPSC
- 12352203
- Western Blot (WB)
- 1:2,000 - 1:10,000
- Immunoprecipitation (IP)
- 2 - 5 µg/mg lysate
- Target Sentence
- Ubiquitin fusion degradation protein 1 homolog (UFD1) forms a dimer with Npl4 (nuclear protein localization 4) and can associate with the ATPase, p97/VCP, to form a ternary complex involved in the ubiquitin-proteasome pathway. The UFD1-p97-Npl4 complex functions to recognize ubiquitin-tagged proteins and facilitate their presentation to the 26S proteasome for degradation. This ternary complex has also been shown to play an important role in mitotic spindle disassembly. Hemizygosity in the gene which encodes UFD1 (UFD1L) is the cause of some catch 22-associated developmental defects. Additionally, the UFD1L gene has also been implicated in the neurodevelopment al origin of schizophrenia.
- Product Link
- http://www.bethyl.com/product/A301-876A
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